The TP53 Gene and Its Role in Cancer - Verywell Health The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged Mutations in the TP53 gene are found in over 50% of cancer cases and can lead to increased cancer growth
p53 - Wikipedia p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation [5] As such, p53 has been
TP53 gene: MedlinePlus Genetics The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53) This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way
The TP53 tumor suppressor gene: From molecular biology to clinical . . . Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology TP53 is the most frequently mutated gene in human malignancies, 50% of which carry alterations to it
Definition of TP53 gene - NCI Dictionary of Cancer Terms A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death Mutations (changes) in the TP53 gene may cause cancer cells to grow and spread in the body
TP53 Mutations (Li-Fraumeni Syndrome): Risks Options People who are born with changes—called mutations—in the TP53 gene have a syndrome known as Li-Fraumeni syndrome and an increased risk for many different types of cancer
TP53 Gene Mutation and Cancer Risk - Everyday Health TP53 is a gene located on chromosome 17 that, when normal, stops cells from growing and dividing You can inherit a TP53 mutation from your parents or develop one later in life
Microsoft Word - TP53_fact_sheet_2023 - Massachusetts General Hospital What does it mean to have a TP53 pathogenic variant? Having a TP53 pathogenic variant, also known as a mutation, means a person has a version of the TP53 gene that does not work properly This may cause a cancer predisposition condition called Li-Fraumeni syndrome (LFS) or LFS-like syndrome
TP53: The Tumor Suppressor Gene and Its Role in Cancer The TP53 gene provides instructions for making a protein called tumor protein p53 This protein acts as a tumor suppressor, a type of protein that regulates cell division