Skin sensitisation - ECHA All of the respective OECD TGs 442C to 442E describe scope and limitation of each individual method under that respective test guideline All methods described below have been included into the Defined Approach Guideline (OECD 497)
Direct Peptide Reactivity Assay (DPRA, OECD 442C) Trained by the developers of this assay (Procter Gamble), IIVS offers this service in compliance with the OECD 442C test guideline as well as Good Laboratory Practices for regulatory submissions
Teste de ativação de reatividade peptídica direta in vitro (OCDE . . . O teste de reatividade peptídica direta (DPRA) (OECD 442C) é um método de teste químico que modela a via de resultado negativo na sensibilização da pele, o primeiro grande evento na reatividade de proteínas com a pele
Test No. 442C: In Chemico Skin Sensitisation - Flashpoint OECD (2019), Performance Standards for the assessment of proposed similar or modified in vitro skin sensitisation DPRA and ADRA test methods, Series on Testing Assessment No 303, Organisation for Economic Cooperation and Development, Paris
In Chemico Skin Sensitisation OECD (2010), Test No 429: Skin Sensitisation: Local Lymph Node Assay, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, https: doi org 10 1787 9789264071100-en
OECD TG 442C In Chemico Skin Sensitization Assay (DPRA) OECD TG 442C: In Chemico Skin Sensitisation Test - This guideline outlines the principles and procedures for conducting in chemico skin sensitization tests using DPRA
OECD 442C: Direct peptide reactivity assay (DPRA) for skin . . . - Labcorp The test, adopted by the OECD and the EU, measures the reactivity of a test compound with model synthetic peptides containing either lysine or cysteine The assay is used to test between skin sensitizers and non-sensitizers
OCDE 442 e Sensibilização In Vitro da Pele: Métodos e Fluxo de . . . O método para testar a ativação de células dendríticas (DC) corresponde à OCDE 442E, contendo três testes: i) Teste de Ativação de Linhagem Celular Humana (h-CLAT), que mede, por citometria de fluxo, os níveis de expressão de marcadores de superfície ligados à maturação das DC, ou seja, CD86 e CD54;
Direct Peptide Reactivity Assay (DPRA) - Eurofins Scientific The DPRA is validated by the EURL ECVAM (European Union Reference Laboratory for Alternatives to Animal Testing) and is performed in accordance with the OECD guidance OECD 442C at Eurofins BioPharma Product Testing Munich GmbH1, 3 with chemicals, cosmetics or personal care products and pharmaceuticals