- Irritability, Anger Indicators of Complex, Severe Depression
Symptoms of irritability and anger during a major depressive episode signal a more complex, chronic, and severe form of major depressive disorder, a new study indicates
- Pramipexole Augmentation Benefits Resistant Depression
Augmenting antidepressant treatment with pramipexole led to a significant reduction in symptoms relative to placebo in treatment-resistant major depressive disorder (MDD) at 12 weeks, a trial
- Add-On D-Serine Shows Promise in Severe Depression - Medscape
Adjunctive D-serine fails to outperform placebo in major depressive disorder but offers benefit in severe cases, especially along with higher-dose standard medications, a trial shows
- Lurasidone Reduces Depression Across Mental Health Diagnoses - Medscape
A meta-analysis reveals that lurasidone outperforms placebo in alleviating depressive symptoms across schizophrenia, bipolar disorder, and major depressive disorder
- Novel SNRI Promising for Major Depression: Phase 2 Data - Medscape
A phase 2 trial suggests that the novel SNRI ammoxetine may effectively treat major depressive disorder while avoiding some side effects common to other antidepressants
- FDA Clears Accelerated TMS Protocol for Major Depression - Medscape
The FDA has cleared an accelerated protocol for a transcranial magnetic stimulation system in the treatment of depression and anxiety symptoms in major depressive disorder
- Doubt Cast on the Need for Long-Term Antidepressant Tapering
Most participants had major depressive disorder, but there were a wide range of conditions including generalized anxiety disorder, panic disorder, fibromyalgia, premenstrual dysphoric disorder
- Rethinking Treatment-Resistant Depression: New Hope Ahead?
A type of major depressive disorder, TRD fails to improve after multiple standard treatments However, the lack of a consensus definition makes it difficult to determine its true prevalence and
- A Low-Carb FIx for Depression? - Medscape
Jasmine Sawhne, MD, MBA Previous research has indicated the keto diet may be beneficial for patients with major depressive disorder and bipolar disorder
- Promising Results for Drug for Depression Plus Insomnia - Medscape
Seltorexant, an investigational drug being developed by Johnson Johnson, met all primary and secondary endpoints in a phase 3 trial of patients with major depressive disorder (MDD) with insomnia
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